Article
Allele-specific disparity in breast cancer.
BMC medical genomics - 21 Dec 2011
Kaveh Fatemeh, Edvardsen Hege, Børresen-Dale Anne-Lise, N Kristensen Vessela, Solvang Hiroko K
Abstract excerpt
BACKGROUND: In a cancer cell the number of copies of a locus may vary due to amplification and deletion and these variations are denoted as copy number alterations (CNAs). We focus on the disparity of CNAs in tumour samples, which were compared to those in blood in order to identify the directional loss of heterozygosity. METHODS: We propose a numerical algorithm and apply it to data from the Illumina 109K-SNP...
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