Article
Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.
Epigenetics - 3 May 2016
O'Sullivan Dylan E, Johnson Kevin C, Skinner Lucy, Koestler Devin C, Christensen Brock C
Abstract excerpt
The development and progression of invasive breast cancer is characterized by alterations to the genome and epigenome. However, the relationship between breast tumor characteristics, disease subtypes, and patient outcomes with the cumulative burden of these molecular alterations are not well characterized. We determined the average departure of tumor DNA methylation from adjacent normal breast DNA methylation...
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