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Article

Computational analysis of whole-genome differential allelic expression data in human.

PLoS computational biology - 8 Jul 2010

Wagner James R, Ge Bing, Pokholok Dmitry, Gunderson Kevin L, Pastinen Tomi, Blanchette Mathieu

Abstract excerpt

Allelic imbalance (AI) is a phenomenon where the two alleles of a given gene are expressed at different levels in a given cell, either because of epigenetic inactivation of one of the two alleles, or because of genetic variation in regulatory regions. Recently, Bing et al. have described the use of genotyping arrays to assay AI at a high resolution (approximately 750,000 SNPs across the autosomes). In this paper,...

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PMID: 20628616
DOI: 10.1371/journal.pcbi.1000849
PMCID: PMC2900287

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