Article

Monoallelic expression characterizes a distinct molecular and clinical group of breast tumors

2025-12-12

Abstract excerpt

In diploid cells, allelic imbalance occurs when gene alleles are expressed at different levels. To investigate the allelic imbalance landscape in tumor samples, we developed Interval-Based Allelic Imbalance Detection (IB-Aid), a quantitative framework that uses interval arithmetic to robustly distinguish monoallelic from biallelic gene expression by computing confidence intervals based on sequencing measurement un...

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Literature Corpus work: e8f5a945-fad9-51da-9d4e-3c5c7936119f
DOI: 10.64898/2025.12.09.692870

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