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Article

Allele-specific copy number analysis of tumors.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2010

Van Loo Peter, Nordgard Silje H, Lingjærde Ole Christian, Russnes Hege G, Rye Inga H, Sun Wei, Weigman Victor J, Marynen Peter, Zetterberg Anders, Naume Bjørn, Perou Charles M, Børresen-Dale Anne-Lise, Kristensen Vessela N

Abstract excerpt

We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of tumors), to accurately dissect the allele-specific copy number of solid tumors, simultaneously estimating and adjusting for both tumor ploidy and nonaberrant cell admixture. This allows calculation of "ASCAT profiles" (genome-wide...

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Identifiers

PMID: 20837533
DOI: 10.1073/pnas.1009843107
PMCID: PMC2947907

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