Article

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

2017-08-22

Abstract excerpt

<h4>Summary</h4> Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e. the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally-arising heteroplasmy have not been experimentally studied to date....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2df81e7f-ce34-54e5-b157-17472514ae3f
DOI: 10.1101/179622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in miceDOI 10.1101/179622Read

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.Semantic proximity Read

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.Semantic proximity Read

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice as they ageSemantic proximity Read

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in miceSemantic proximity Read

The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouseSemantic proximity Read

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease.Semantic proximity Read

The mtDNA Mutation Spectrum in the Polg Mutator Mouse Reveals Germline and Somatic SelectionSemantic proximity Read

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy.Semantic proximity Read

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.Semantic proximity Read

A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation.Semantic proximity Read

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice.Semantic proximity Read

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout agingSemantic proximity Read