Article
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.
Scientific reports - 12 Apr 2018
Hirose Misa, Schilf Paul, Gupta Yask, Zarse Kim, Künstner Axel, Fähnrich Anke, Busch Hauke, Yin Junping, Wright Marvin N, Ziegler Andreas, Vallier Marie, Belheouane Meriem, Baines John F, Tautz Diethard, Johann Kornelia, Oelkrug Rebecca, Mittag Jens, Lehnert Hendrik, Othman Alaa, Jöhren Olaf, Schwaninger Markus, Prehn Cornelia, Adamski Jerzy, Shima Kensuke, Rupp Jan, Häsler Robert, Fuellen Georg, Köhling Rüdiger, Ristow Michael, Ibrahim Saleh M
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence...
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