Mammalian mitochondrial genetics: heredity, heteroplasmy and disease.

doi:10.1016/s0168-9525(97)01266-3

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Article

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease.

Trends in genetics : TIG - 1 Nov 1997

Lightowlers R N, Chinnery P F, Turnbull D M, Howell N

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is present at high copy number (10(3)-10(4) copies) in virtually all cells of the body. The mitochondrial genome shows strict maternal inheritance and the vast majority of copies are identical at birth (homoplasmy). Occasionally, a subpopulation of mtDNA molecu...

Topics

Animals
DNA, Mitochondrial
Female
Humans
Mitochondrial Myopathies
Models, Genetic
Mutation
Recombination, Genetic

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