Article

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice as they age

2023-06-15

Abstract excerpt

One-carbon metabolism is a complex network of metabolic reactions that are essential for cellular function including DNA synthesis. Vitamin B12 and folate are micronutrients that are utilized in this pathway and their deficiency can result in the perturbation of one-carbon metabolism and subsequent perturbations in DNA replication and repair. This effect has been well characterized in nuclear DNA but to date, mito...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b975d7e-910c-54f5-aa4d-990eaf6225f5
DOI: 10.1101/2023.06.15.545050

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice as they ageDOI 10.1101/2023.06.15.545050Read

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in miceSemantic proximity Read

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in miceSemantic proximity Read

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.Semantic proximity Read

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.Semantic proximity Read

Independent impacts of aging on mitochondrial DNA quantity and quality in humans.Semantic proximity Read

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.Semantic proximity Read

Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex ISemantic proximity Read

Mitochondrial DNA Variations Modulate Alveolar Epithelial Mitochondrial Function and Oxidative Stress in Newborn Mice Exposed to HyperoxiaSemantic proximity Read

Mitochondrial dysfunction reshapes methyl-group allocation in skeletal muscleSemantic proximity Read

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesisSemantic proximity Read

Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profilesSemantic proximity Read

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.Semantic proximity Read