Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

doi:10.1038/nature18618

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Article

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Nature - 28 Jul 2016

Latorre-Pellicer Ana, Moreno-Loshuertos Raquel, Lechuga-Vieco Ana Victoria, Sánchez-Cabo Fátima, Torroja Carlos, Acín-Pérez Rebeca, Calvo Enrique, Aix Esther, González-Guerra Andrés, Logan Angela, Bernad-Miana María Luisa, Romanos Eduardo, Cruz Raquel, Cogliati Sara, Sobrino Beatriz, Carracedo Ángel, Pérez-Martos Acisclo, Fernández-Silva Patricio, Ruíz-Cabello Jesús, Murphy Michael P, Flores Ignacio, Vázquez Jesús, Enríquez José Antonio

Abstract excerpt

Human mitochondrial DNA (mtDNA) shows extensive within population sequence variability. Many studies suggest that mtDNA variants may be associated with ageing or diseases, although mechanistic evidence at the molecular level is lacking. Mitochondrial replacement has the potential to prevent transmission of disease-causing oocyte mtDNA. However, extension of this technology requires a comprehensive understanding...

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PMID: 27383793
DOI: 10.1038/nature18618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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