Article

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout aging

2023-03-08

Abstract excerpt

Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here, we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evolution of the mt-genome in different tissues throughout aging. We used ultra-sensitive Duplex Sequencing to profile ∼2.5 million mt-genomes across five mitochondrial haplotypes...

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Literature Corpus work: de6e4e64-ba45-56ec-b748-7f6e8b234a2a
DOI: 10.1101/2023.03.06.531392

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