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Article

The mtDNA Mutation Spectrum in the Polg Mutator Mouse Reveals Germline and Somatic Selection

2021-06-30

Abstract excerpt

<h4>Background: </h4> Mitochondrial DNA (mtDNA) codes for products necessary for electron transport and mitochondrial gene translation. mtDNA mutations can lead to human disease and influence organismal fitness. The PolG mutator mouse lacks mtDNA proofreading function and rapidly accumulates mtDNA mutations, making it a model for examining the causes and consequences of mitochondrial mutations. Premature aging in...

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Literature Corpus work
2a366838-096f-5962-a3ee-22fd21802125
DOI
10.21203/rs.3.rs-659185/v1
Open publication

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The mtDNA Mutation Spectrum in the Polg Mutator Mouse Reveals Germline and Somatic SelectionDOI 10.21203/rs.3.rs-659185/v1
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