Article
A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation.
International journal of molecular sciences - 20 Jan 2021
Schilf Paul, Künstner Axel, Olbrich Michael, Waschina Silvio, Fuchs Beate, Galuska Christina E, Braun Anne, Neuschütz Kerstin, Seutter Malte, Bieber Katja, Hellberg Lars, Sina Christian, Laskay Tamás, Rupp Jan, Ludwig Ralf J, Zillikens Detlef, Busch Hauke, Sadik Christian D, Hirose Misa, Ibrahim Saleh M
Abstract excerpt
Several genetic variants in the mitochondrial genome (mtDNA), including ancient polymorphisms, are associated with chronic inflammatory conditions, but investigating the functional consequences of such mtDNA polymorphisms in humans is challenging due to the influence of many other polymorphisms in both mtDNA and the nuclear genome (nDNA). Here, using the conplastic mouse strain B6-mtFVB, we show that in mice, a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.