Article
The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse
16 Sept 2009
Abstract excerpt
Mitochondria are organelles of all nucleated cells, and variations in mtDNA sequence affect a wide spectrum of human diseases. However, animal models for mtDNA-associated diseases are rare, making it challenging to explore mechanisms underlying the contribution of mitochondria. Here, we identify a polymorphism in the mitochondrial genome, G-to-T at position 7778, which results in an aspartic acid-to-tyrosine...
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