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Article

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice.

Aging cell - 1 Sept 2024

Liu Fuyan, Sun Xiaolin, Wei Cai, Ji Liu, Song Yali, Yang Chenlu, Wang Yue, Liu Xin, Wang Daqing, Kang Jingmin

Abstract excerpt

Mitochondria play a crucial role in numerous biological processes; however, limited methods and research have focused on revealing mitochondrial heterogeneity at the single-cell level. In this study, we optimized the DNBelab C4 single-cell ATAC (assay for transposase-accessible chromatin) sequencing workflow for single-cell mitochondrial sequencing (C4_mtscATAC-seq). We validated the effectiveness of our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39422985
DOI: 10.1111/acel.14242
PMCID: PMC11488324

Genes

KLF15
NRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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