Article

Finding the perfect promoter: Correlating single-cell transcriptome data with gene drive performance

2025-10-08

Abstract excerpt

Gene drive can control pathogen transmission or suppress vector populations by spreading drive alleles with super-Mendelian inheritance. CRISPR homing drive currently represents the most powerful type, and regulating Cas9 expression with specific promoters has been effective for improving drive performance. However, selecting these is often a major challenge. Here, we evaluated 35 Cas9 constructs driven by distinc...

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Literature Corpus work: 2da25b29-3f96-5112-8495-46abdc342207
DOI: 10.1101/2025.10.08.681126

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