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Design and analysis of CRISPR-based underdominance toxin-antidote gene drives

2019-12-02

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR gene drive systems offer a mechanism for transmitting a desirable transgene throughout a population for purposes ranging from vector-borne disease control to invasive species suppression. In this simulation study, we assess the performance of several CRISPR-based underdominance gene drive constructs employing toxin-antidote principles. These drives disrupt the wild-type version of an esse...

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Literature Corpus work
550594b5-9561-5083-9907-d6ba5d670804
DOI
10.1101/861435
Open publication

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Design and analysis of CRISPR-based underdominance toxin-antidote gene drivesDOI 10.1101/861435
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