Finding the perfect promoter for Cas9 in homing gene drives using single cell transcriptome data.

doi:10.1038/s41467-026-76107-0

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Article

Finding the perfect promoter for Cas9 in homing gene drives using single cell transcriptome data.

Nature communications - 25 Jul 2026

Wu Yingke, Xia Yunchen, Yao Ziyin, Chen Weizhe, Jia Xihua, Liang Nan, Champer Jackson

Abstract excerpt

Gene drive can modify or suppress vector populations by spreading drive alleles. In CRISPR homing drives, regulating Cas9 expression has been effective for improving drive performance, but selecting suitable promoters is often a major challenge. Here, we evaluate 35 Cas9 constructs with distinct promoters in Drosophila melanogaster and identify associations between drive performance and single-cell RNA expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42642425
DOI: 10.1038/s41467-026-76107-0
PMCID: PMC13507122

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