Cross-species meta-analysis reveals determinants of homing gene drive performance

Abstract excerpt

Homing gene drives can bias their inheritance above Mendelian expectations, but reported outcomes vary widely. We compiled a cross-species dataset of nearly one million scored progeny from 42 publications reporting CRISPR/Cas9 endonuclease-based gene drives in 10 model, pest, and vector species. Using multilevel meta-analytic models, we evaluate biological, cross, and transgene design factors as predictors of bias...

Topics

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• Animals, Genetically Modified
• CRISPR-Cas Systems
• Diptera
• Gene Editing
• Genes, X-Linked
• Models, Theoretical
• RNA, Guide, CRISPR-Cas Systems
• Transgenes

Identifiers and source

Literature Corpus work

2d4133e8-cfba-579d-b27e-cf88b6871bee

DOI

10.64898/2026.02.28.708699