Article

Does blood pressure level matter more in individuals with higher genetic risk of dementia? A polygenic interaction study in the UK Biobank

2025-07-15

Abstract excerpt

<h4>Background & Aims</h4> The causal role of blood pressure (BP) in dementia remains debated. BP may act as an effect modifier; whereby elevated pressure accelerates cognitive decline in the presence of existing neurodegenerative or cerebrovascular pathology, through vascular injury and impaired cerebral homeostasis. We examine whether genetic liability to dementia interacts with BP to influence risk of dementia...

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Literature Corpus work: 2d931fd5-9745-5380-a337-3c278c8c3201
DOI: 10.1101/2025.07.14.25331521

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