Article

Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study

2025-06-23

Abstract excerpt

<h4>Background</h4> Vascular dementia (VaD) is the second most common cause of dementia, yet its risk factors and biological mechanisms remain poorly understood. <h4>Objective</h4> To identify causes and consequences of VaD by developing a polygenic risk score (PRS) for VaD and conducting a phenome-wide association study (PheWAS), followed by Mendelian randomization (MR) analyses using data from the UK Biobank. <h...

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Literature Corpus work: cf309ba3-67b4-546d-8813-942d756fcdd5
DOI: 10.1101/2025.06.23.25330106

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