Article

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK Biobank

2026-01-24

Abstract excerpt

<h4>Introduction</h4> Both genetic and modifiable lifestyle factors contribute to dementia risk, yet their separate and joint predictive value for dementia and its intermediate markers (cognitive function and brain structure), is unclear. This study evaluated APOE ε4 status, AD polygenic risk (excluding APOE), and the updated LIBRA2 index (14 modifiable factors) in predicting dementia, cognition, and brain imagin...

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Literature Corpus work: 87b4a667-540c-5df6-88e8-c864efe483e5
DOI: 10.64898/2026.01.23.26344680

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