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Article

Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population.

Neurology - 14 Jul 2026

Kim Daeeun, McInerney Katelyn, Dagli Chaitali, Armstrong Nicole D, Cushman Mary, Bennett Aleena, Blue Elizabeth E, Sofer Tamar, Sawyer Russell P, Yuan Ya, Crowe Michael, Judd Suzanne E, Olson Nels C, Irvin Marguerite R, Raffield Laura M

Abstract excerpt

BACKGROUND AND OBJECTIVES: Late-life dementia has a strong heritable component. While the APOE ɛ4 allele is the strongest genetic risk factor of Alzheimer disease (AD), polygenic risk factors also play a significant role. Cardiometabolic diseases (CMDs) and their risk factors predict dementia in many cohorts, but how genetic predictors of CMD influence dementia-related outcomes remains unclear. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42234953
DOI: 10.1212/WNL.0000000000218163
PMCID: PMC13240660

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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