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High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank

27 Dec 2020

Abstract excerpt

Background Findings from randomized controlled trials have yielded conflicting results on the association between blood pressure (BP) and dementia traits. We tested the hypothesis that a causal relationship exists between systolic BP (SBP) and/or diastolic BP (DBP) and risk of Alzheimer's disease (AD). Methods We performed a generalized summary Mendelian randomization (GSMR) analysis using summary statistics of a...

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PMID: 33766239
DOI: 10.1016/j.biopsych.2020.12.015

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