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Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.

Atherosclerosis - 1 Aug 2026

Luo Jiao, Rasmussen Ida Juul, Thomassen Jesper Qvist, Frikke-Schmidt Ruth

Abstract excerpt

BACKGROUND: The 2024 Lancet Commission report identifies 14 modifiable risk factors that may prevent half of dementia. The causal nature of these associations remains however unclear. We aimed to establish robust causal estimates for modifiable cardiovascular risk factors and dementia, offering tangible targets for effective dementia prevention. METHODS: We selected independent variants from the largest genomic...

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PMID: 42385644
DOI: 10.1016/j.atherosclerosis.2026.120824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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