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Article

Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2023

Littlejohns Thomas J, Collister Jennifer A, Liu Xiaonan, Clifton Lei, Tapela Neo M, Hunter David J

Abstract excerpt

INTRODUCTION: There is inconsistent evidence on whether genetic risk for dementia modifies the association between hypertension and dementia. METHODS: In 198,965 dementia-free participants aged ≥60 years, Cox proportional-hazards models were used to investigate the association between hypertension and incident dementia. A polygenic risk score (PRS) based on 38 non-apolipoprotein E (APOE) single nucleotide...

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PMID: 35439339
DOI: 10.1002/alz.12680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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