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Article

Prioritizing Modifiable Risk Factors for Dementia Prevention across the Spectrum of Genetic Susceptibility: A Prospective Cohort Study.

Annals of neurology - 1 Dec 2025

Tian Fei, Zhao Jinde, Chen Lan, Wei Shengtao, Lin Hualiang

Abstract excerpt

OBJECTIVE: Various modifiable risk factors have been identified for dementia, but it remains unclear whether these associations and importance vary according to genetic predisposition. METHODS: We included 182,473 dementia-free individuals from United Kingdom (UK) Biobank cohort. We calculated the hazard ratios (HRs) and population-attributable fractions (PAF) of 11 modifiable risk factors (smoking status,...

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Identifiers

PMID: 41085200
DOI: 10.1002/ana.78060

Genes

APOE
ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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