Article
Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia.
JAMA network open - 1 May 2024
Sargurupremraj Muralidharan, Soumaré Aicha, Bis Joshua C, Surakka Ida, Jürgenson Tuuli, Joly Pierre, Knol Maria J, Wang Ruiqi, Yang Qiong, Satizabal Claudia L, Gudjonsson Alexander, Mishra Aniket, Bouteloup Vincent, Phuah Chia-Ling, van Duijn Cornelia M, Cruchaga Carlos, Dufouil Carole, Chêne Geneviève, Lopez Oscar L, Psaty Bruce M, Tzourio Christophe, Amouyel Philippe, Adams Hieab H, Jacqmin-Gadda Hélène, Ikram Mohammad Arfan, Gudnason Vilmundur, Milani Lili, Winsvold Bendik S, Hveem Kristian, Matthews Paul M, Longstreth W T, Seshadri Sudha, Launer Lenore J, Debette Stéphanie
Abstract excerpt
Importance: Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain. Objective: To investigate the causal association between white matter hyperintensity (WMH) burden, clinical stroke, blood pressure (BP), and dementia risk, while accounting for potential epidemiologic biases. Design, Setting, and Participants: This...
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