Article
Next stop for the CRISPR revolution: RNA-guided epigenetic regulators.
The FEBS journal - 1 Sept 2016
Vora Suhani, Tuttle Marcelle, Cheng Jenny, Church George
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins offer a breakthrough platform for cheap, programmable, and effective sequence-specific DNA targeting. The CRISPR-Cas system is naturally equipped for targeted DNA cutting through its native nuclease activity. As such, groups researching a broad spectrum of biological organisms have quickly adopted the...
Topics
- Animals
- CRISPR-Cas Systems
- Cell Differentiation
- Epigenesis, Genetic
- Epigenetic Repression
- Gene Editing
- Humans
- Phenotype
- RNA Interference
- RNA, Guide, CRISPR-Cas Systems
- RNA, Long Noncoding