Article

CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomes

2014-05-12

Abstract excerpt

CRISPR/Cas9 systems enable many molecular activities to be efficiently directed in vivo to user-specifiable DNA sequences of interest, including generation of dsDNA cuts and nicks, transcriptional activation and repression, and fluorescence. CRISPR targeting relies on base pairing of short RNA transcripts with their target DNA sequences that must also be adjacent to fixed DNA motifs. However, rules for Cas9 targe...

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Identifiers and source

Literature Corpus work: 8136454c-096e-56c1-8643-a6e3d46f1616
DOI: 10.1101/005074

Open publication

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