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Article

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Cell - 19 Aug 2021

Bowles Kathryn R, Silva M Catarina, Whitney Kristen, Bertucci Taylor, Berlind Joshua E, Lai Jesse D, Garza Jacob C, Boles Nathan C, Mahali Sidhartha, Strang Kevin H, Marsh Jacob A, Chen Cynthia, Pugh Derian A, Liu Yiyuan, Gordon Ronald E, Goderie Susan K, Chowdhury Rebecca, Lotz Steven, Lane Keith, Crary John F, Haggarty Stephen J, Karch Celeste M, Ichida Justin K, Goate Alison M, Temple Sally

Abstract excerpt

Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used human induced pluripotent stem cell (iPSC)-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations because of the mutation that precede neurodegeneration. At 2 months, mutant organoids show...

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Identifiers

PMID: 34314701
DOI: 10.1016/j.cell.2021.07.003
PMCID: PMC8635409

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