Article

Conserved gene signatures shared among <i>MAPT</i> mutations reveal defects in calcium signaling

2022-06-14

Abstract excerpt

More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-tau). However, early pathogenic events that lead to disease and the degree to which they are common across MAPT mutations remain poorly understood. The goal of this study is to determine whether there is a common molecular signature of FTLD-Tau. To do this, we analyzed genes differential...

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Literature Corpus work: 494abc9d-3ec4-5130-87b3-025d972074bc
DOI: 10.1101/2022.06.10.22276260

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