Article

Elevated 4R-tau in Astrocytes From Asymptomatic Carriers of the MAPT 10+16 Mutation

2020-12-04

Abstract excerpt

<title>Abstract</title> <p>The <italic>MAPT</italic> 10+16 intronic mutation causes frontotemporal lobar degeneration (FTLD) by increasing expression of four-repeat (4R)-tau isoforms. We investigated the potential role for astrocytes in the pathogenesis of FTLD by studying the expression of 4R-tau. We derived astrocytes and neurons from induced pluripotent stem cells from two asymptomatic 10+16 carriers and, comp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad1c28a2-fd22-5345-a8e0-f14535739bcb
DOI: 10.21203/rs.3.rs-117443/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elevated 4R-tau in Astrocytes From Asymptomatic Carriers of the MAPT 10+16 MutationDOI 10.21203/rs.3.rs-117443/v1Read

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.Semantic proximity Read

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic functionSemantic proximity Read

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.Semantic proximity Read

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes.Semantic proximity Read

Determinants of Astrocytic Pathology in Stem Cell Models of Primary TauopathiesSemantic proximity Read

Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaSemantic proximity Read

Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia.Semantic proximity Read

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau.Semantic proximity Read

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with<i>MAPT</i>mutationsSemantic proximity Read

Conserved gene signatures shared among <i>MAPT</i> mutations reveal defects in calcium signalingSemantic proximity Read

MAPT Isoforms: Differential Transcriptional Profiles Related to 3R and 4R Splice VariantsSemantic proximity Read

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.Semantic proximity Read