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Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with<i>MAPT</i>mutations

27 Jul 2015

Abstract excerpt

Tauopathies, such as Alzheimer’s disease, some cases of frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy, are characterized by aggregates of the microtubule-associated protein tau, which are linked to neuronal death and disease development and can be caused by mutations in the MAPT gene. Six tau isoforms are present in the adult human brain and they differ by the presence of...

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PMID: 26220942
DOI: 10.1093/brain/awv222

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Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with<i>MAPT</i>mutationsPMID 26220942Read ↗

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