Article
Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States
2026-02-25
Abstract excerpt
<h4>Background</h4> Genome-wide association studies (GWAS), with independent replication in large European consortia, have identified a common nonsense variant in IL-34 (Y213X) as a genetic risk factor for late-onset Alzheimer’s disease (AD). However, the biological consequences of this IL-34 mutation in humans, its prevalence in the population, and the mechanisms by which IL-34-Y213X alters microglial homeostasi...
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Identifiers and source
- Literature Corpus work
- 623e7904-3747-58cd-9c21-bf7449005997
- DOI
- 10.64898/2026.02.21.26346696