Article

STING–IFN–CH25H lipid axis links innate immune activation to tau pathology

2025-12-18

Abstract excerpt

Genetic risk for Alzheimer’s disease is strongly enriched in pathways governing microglial activation and cholesterol metabolism, yet how these processes converge to drive neurodegeneration remains unclear. Here, we identify the oxysterol 25-hydroxycholesterol (25- HC) as a pathogenic lipid downstream of the cGAS-STING–IFN pathway. In models of tau pathology, interferon signaling induces Cholesterol 25-hydroxylase...

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Literature Corpus work: c46d15f6-c719-5bc5-8697-058d21887f83
DOI: 10.64898/2025.12.16.694702

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