Article

Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse model

2023-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles in addition to neuroinflammation and changes in brain lipid metabolism. Recent findings have demonstrated that microglia are key drivers of neurodegeneration in tauopathy mouse models. A subset of microglia referred to as disease-associated microglia (DAM) display gene signatures signifying changes in proinf...

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Literature Corpus work: 40d6cb44-7d87-5d37-90c4-261977135d19
DOI: 10.1101/2023.09.08.556884

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