Article

Prognostically favorable immune responses to ovarian cancer are distinguished by self-reactive intra-epithelial plasma cells

2025-05-14

Abstract excerpt

<h4>SUMMARY</h4> Tumor-infiltrating B cells (TIL-Bs) are strongly associated with patient survival; however, the underlying mechanisms are poorly understood. Using integrated single-cell and spatial biology approaches, we defined at clonal resolution the molecular phenotypes, tumor reactivity patterns, and microenvironmental locations of TIL-Bs in high-grade serous ovarian cancer (HGSC). Prognostic benefit was as...

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Literature Corpus work: 2cd36c67-ca32-5232-a40b-72a8dc0acd06
DOI: 10.1101/2025.05.12.652297

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