Article

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

2021-08-25

Abstract excerpt

<h4>ABSTRACT</h4> High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability patterned by distinct mutational processes, intratumoral heterogeneity and intraperitoneal spread. We investigated determinants of immune recognition and evasion in HGSOC to elucidate co- evolutionary processes underlying malignant progression and tumor immunity. Mutational processes and anatomic sites of tum...

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Literature Corpus work: 16cb21d0-d84a-5181-9346-ff2e1a448558
DOI: 10.1101/2021.08.24.454519

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