Article
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer.
Nature communications - 11 Feb 2022
Launonen I-M, Lyytikäinen N, Casado J, Anttila E A, Szabó A, Haltia U-M, Jacobson C A, Lin J R, Maliga Z, Howitt B E, Strickland K C, Santagata S, Elias K, D'Andrea A D, Konstantinopoulos P A, Sorger P K, Färkkilä A
Abstract excerpt
The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the BRCA1/2 genes. We aimed to discover how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. Using a highly multiplex immunofluorescence and image analysis we generate spatial proteomic data...
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