Article

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

2021-09-13

Abstract excerpt

<title>Abstract</title> <p>The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the BRCA1/2 genes. We aimed to discover how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. Using a highly multiplex immunofluorescence and image analysis we gene...

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Literature Corpus work: a38feec8-ede1-52a4-8794-915d36a0eef5
DOI: 10.21203/rs.3.rs-257705/v2

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