Article
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes.
Cell - 22 Aug 2024
Yang Yu, Chen Xueyan, Pan Jieying, Ning Huiheng, Zhang Yaojun, Bo Yufei, Ren Xianwen, Li Jiesheng, Qin Shishang, Wang Dongfang, Chen Min-Min, Zhang Zemin
Abstract excerpt
Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells (TIBs) is important for advancing our understanding of their role in cancer development. Here, we establish a comprehensive resource of human B cells by integrating single-cell RNA sequencing data of B cells from 649 patients across 19 major cancer types. We demonstrate substantial heterogeneity in their total abundance...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.