Article

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes

2024-12-03

Abstract excerpt

The tumor microenvironment (TME) is a complex network of interactions between malignant and host cells, yet its orchestration in advanced high-grade serous ovarian carcinoma (HGSC) remains poorly understood. We present a comprehensive single-cell spatial atlas of 280 metastatic HGSCs, integrating high-dimensional imaging, genomics, and transcriptomics. Using 929 single-cell maps, we identify distinct spatial domai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd85185d-630e-5c45-9efd-4211f2613835
DOI: 10.1101/2024.11.29.626039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomesDOI 10.1101/2024.11.29.626039Read

Characterizing intra- and inter-tumor heterogeneity in Ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomicsSemantic proximity Read

Single-cell spatial atlas of tertiary lymphoid structures in ovarian cancerSemantic proximity Read

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer.Semantic proximity Read

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancerSemantic proximity Read

The spatial structure of the tumor immune microenvironment can explain and predict patient response in high-grade serous carcinomaSemantic proximity Read

Single-Cell RNA Sequencing Reveals the Tissue Architecture in Human High-Grade Serous Ovarian CancerSemantic proximity Read

Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of ChemotherapySemantic proximity Read

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity Read

A TEMPORAL MODEL OF TUMOR-IMMUNE DYNAMICS IN HIGH GRADE SEROUS OVARIAN CANCERSemantic proximity Read

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironmentSemantic proximity Read

Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneitySemantic proximity Read

The interface of malignant and immunologic clonal dynamics in high-grade serous ovarian cancerSemantic proximity Read