Article
Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.
Cell - 14 Jun 2018
Zhang Allen W, McPherson Andrew, Milne Katy, Kroeger David R, Hamilton Phineas T, Miranda Alex, Funnell Tyler, Little Nicole, de Souza Camila P E, Laan Sonya, LeDoux Stacey, Cochrane Dawn R, Lim Jamie L P, Yang Winnie, Roth Andrew, Smith Maia A, Ho Julie, Tse Kane, Zeng Thomas, Shlafman Inna, Mayo Michael R, Moore Richard, Failmezger Henrik, Heindl Andreas, Wang Yi Kan, Bashashati Ali, Grewal Diljot S, Brown Scott D, Lai Daniel, Wan Adrian N C, Nielsen Cydney B, Huebner Curtis, Tessier-Cloutier Basile, Anglesio Michael S, Bouchard-Côté Alexandre, Yuan Yinyin, Wasserman Wyeth W, Gilks C Blake, Karnezis Anthony N, Aparicio Samuel, McAlpine Jessica N, Huntsman David G, Holt Robert A, Nelson Brad H, Shah Sohrab P
Abstract excerpt
High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer cells. Through multi-region study of 212 samples from 38 patients with whole-genome sequencing,...
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