Article

Clonally related tumor-reactive memory B cells reside in primary tumors and lymph nodes of ovarian cancer patients

2024-10-29

Abstract excerpt

<title>Abstract</title> <p>The presence of B cells in tumors is correlated with a positive prognosis in several types of cancers, including high-grade serous ovarian cancer (HGSOC)1–4. These B cells give rise to plasma cells (PCs) that originate from germinal centers (GCs) and secrete tumor-reactive antibodies5,6. GCs also give rise to memory B cells (MBCs)7,8; yet, it is not known if tumor-reactive MBCs form and...

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Literature Corpus work: 2e36b070-392a-5b0f-a24a-00987a012bb2
DOI: 10.21203/rs.3.rs-5310643/v1

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