Article

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

2023-10-19

Abstract excerpt

<h4>SUMMARY</h4> Immune exclusion and evasion are central barriers to the success of immunotherapies and cell therapies in solid tumors. Here we applied single cell spatial and perturbational transcriptomics alongside clinical, histological, and genomic profiling to elucidate immune exclusion and evasion in high-grade serous tubo-ovarian cancer (HGSC). Using high-plex spatial transcriptomics we profiled more than...

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Literature Corpus work: e3639e13-985f-52a2-a0d8-31d7a0dbb359
DOI: 10.1101/2023.10.16.562592

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