Article

Genetic dependencies associated with transcription factor activities in human cancer cell lines

2023-02-23

Abstract excerpt

Transcription factors (TFs) are key components of the aberrant transcriptional programs in cancer cells. In this study, we used TF activity (TFa), inferred from the downstream regulons as a potential biomarker to identify associated genetic vulnerabilities in cancer cells. Our linear model framework, integrating TFa and genome-wide CRISPR knockout datasets identified 1,770 candidate TFa-target pairs across differe...

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Literature Corpus work: 2cc6ecd9-3137-5413-8739-a2f26b6c4a17
DOI: 10.1101/2023.02.23.529701

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