Article
A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization.
Cancer cell - 12 Feb 2024
Pacini Clare, Duncan Emma, Gonçalves Emanuel, Gilbert James, Bhosle Shriram, Horswell Stuart, Karakoc Emre, Lightfoot Howard, Curry Ed, Muyas Francesc, Bouaboula Monsif, Pedamallu Chandra Sekhar, Cortes-Ciriano Isidro, Behan Fiona M, Zalmas Lykourgos-Panagiotis, Barthorpe Andrew, Francies Hayley, Rowley Steve, Pollard Jack, Beltrao Pedro, Parts Leopold, Iorio Francesco, Garnett Mathew J
Abstract excerpt
Genetic screens in cancer cell lines inform gene function and drug discovery. More comprehensive screen datasets with multi-omics data are needed to enhance opportunities to functionally map genetic vulnerabilities. Here, we construct a second-generation map of cancer dependencies by annotating 930 cancer cell lines with multi-omic data and analyze relationships between molecular markers and cancer dependencies...
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