Article

Discovery of novel therapeutic targets in cancer using patient-specific gene regulatory networks

2022-02-01

Abstract excerpt

Most cancer types lack effective targeted therapeutic options and in cancers where first-line targeted therapies are available, treatment resistance is a huge challenge. Recent technological advances enable the use of ATAC-seq and RNA-seq on patient biopsies in a high-throughput manner. Here we present a computational approach that leverages these datasets to identify novel drug targets based on tumor lineage. We...

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Literature Corpus work: 7790c995-5fff-58e5-97f5-dca2f034c74c
DOI: 10.1101/2022.01.31.478503

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