Article

Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programs

2024-01-01

Abstract excerpt

Understanding the role of transcription and transcription factors in cellular identity and disease, such as cancer and autoimmunity, is essential. However, comprehensive data resources for cell line-specific transcription factor-to-target gene annotations are currently limited. To address this, we developed a straightforward method to define regulons that capture the cell-specific aspects of TF binding and transcr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 584cee6b-4819-5ea5-95c6-73d3348b6d82
DOI: 10.1101/2023.12.31.573765

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programsDOI 10.1101/2023.12.31.573765Read

An atlas of TF driven gene programs across human cellsSemantic proximity Read

Native, Spatiotemporal Profiling of the Global Human RegulomeSemantic proximity Read

Joint inference of transcription factor activity and context-specific regulatory networksSemantic proximity Read

Graph-based tracing of dynamically functioning gene circuits in cell fate decisions with isoform resolutionSemantic proximity Read

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell stateSemantic proximity Read

Benchmark and integration of resources for the estimation of human transcription factor activitiesSemantic proximity Read

Large-scale prediction of transcription factor binding across human cell types informs regulatory genomics and reveals promiscuous occupancy associated with chromatin contactsSemantic proximity Read

In vivo measurement and prediction of cell-type-resolved non-coding variant effects in human immunitySemantic proximity Read

Benchmarking tools for transcription factor prioritizationSemantic proximity Read

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.Semantic proximity Read

GET: a foundation model of transcription across human cell typesSemantic proximity Read

Single-Cell Transcriptomics Unveils Gene Regulatory Network PlasticitySemantic proximity Read